Publications

• Salamon, I., Palsule, G., Luo, X., Roque, A., Tucai, S., Khosla, I., Volk, N., Liu, W., Cui, H., Pozzo, V. D., Zalamea, P., Jiao, X., D’Arcangelo, G., Hart, R. P., Rasin, M. R., & Kiledjian, M. (2022). mRNA-Decapping Associated DcpS Enzyme Controls Critical Steps of Neuronal Development. Cerebral cortex (New York, N.Y. : 1991), 32, 1494-1507. PubMed
• Song, X., Gao, H. Y., Herrup, K., & Hart, R. P. (2022). Optimized splitting of mixed-species RNA sequencing data. Journal of bioinformatics and computational biology. PubMed
• Chow, H. M., Sun, J. K., Hart, R. P., Cheng, K. K., Hung, C. H. L., Lau, T. M., & Kwan, K. M. (2021). Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8, e2004993. PubMed
• Lai, D., Kapoor, M., Wetherill, L., Schwandt, M., Ramchandani, V. A., Goldman, D., Chao, M., Almasy, L., Bucholz, K., Hart, R. P., Kamarajan, C., Meyers, J. L., Nurnberger, J. I., Tischfield, J., Edenberg, H. J., Schuckit, M., Goate, A., Scott, D. M., Porjesz, B., Agrawal, A., & Foroud, T. (2020). Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 186, 151-161. PubMed
• Salamon, I., Palsule, G., Luo, X., Roque, A., Tucai, S., Khosla, I., Volk, N., Liu, W., Cui, H., Pozzo, V. D., Zalamea, P., Jiao, X., D’Arcangelo, G., Hart, R. P., Rasin, M. R., & Kiledjian, M. (2021). mRNA-Decapping Associated DcpS Enzyme Controls Critical Steps of Neuronal Development. Cerebral cortex (New York, N.Y. : 1991). PubMed
• Scarnati, M. S., Boreland, A. J., Joel, M., Hart, R. P., & Pang, Z. P. (2020). Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol. Alcohol (Fayetteville, N.Y.), 87, 97-109. PubMed
• Gokhale, S., Lu, W., Zhu, S., Liu, Y., Hart, R. P., Rabinowitz, J. D., & Xie, P. (2020). Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes. Journal of immunology (Baltimore, Md. : 1950), 204, 459-471. PubMed
• Halikere, A., Popova, D., Scarnati, M. S., Hamod, A., Swerdel, M. R., Moore, J. C., Tischfield, J. A., Hart, R. P., & Pang, Z. P. (2020). Modelling the single most common SNP in OPRM1 (A118G) using human neurons generated from two sets of independently targeted isogenic stem cell lines. Molecular psychiatry, 25, 1355. PubMed
• Xu, R., Li, X., Boreland, A. J., Posyton, A., Kwan, K., Hart, R. P., & Jiang, P. (2020). Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. Nature communications, 11, 1577. PubMed
• Popovitchenko, T., Park, Y., Page, N. F., Luo, X., Krsnik, Z., Liu, Y., Salamon, I., Stephenson, J. D., Kraushar, M. L., Volk, N. L., Patel, S. M., Wijeratne, H. R. S., Li, D., Suthar, K. S., Wach, A., Sun, M., Arnold, S. J., Akamatsu, W., Okano, H., Paillard, L., Zhang, H., Buyske, S., Kostovic, I., De Rubeis, S., Hart, R. P., & Rasin, M. R. (2020). Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development. Nature communications, 11, 1674. PubMed
• Fantuzzo, J. A., Robles, D. A., Mirabella, V. R., Hart, R. P., Pang, Z. P., & Zahn, J. D. (2020). Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications. Lab on a chip. PubMed
• Halikere, A., Popova, D., Scarnati, M. S., Hamod, A., Swerdel, M. R., Moore, J. C., Tischfield, J. A., Hart, R. P., & Pang, Z. P. (2019). Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons. Molecular psychiatry. PubMed
• Hart, R.P. (2019) Strategies for Integrating Single-Cell RNA Sequencing Results With Multiple Species. bioRxiv 671115; doi: https://doi.org/10.1101/671115
• Chow, H. M., Cheng, A., Song, X., Swerdel, M. R., Hart, R. P., & Herrup, K. (2019). ATM is activated by ATP depletion and modulates mitochondrial function through NRF1. The Journal of cell biology 218: 909-928. PubMed
• Xu, R., Brawner, A. T., Li, S., Liu, J. J., Kim, H., Xue, H., Pang, Z. P., Kim, W. Y., Hart, R. P., Liu, Y., & Jiang, P. (2019). OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome. Cell stem cell 24:908-926.e8. PubMed
• Grudzien-Nogalska, E., Wu, Y., Jiao, X., Cui, H., Mateyak, M. K., Hart, R. P., Tong, L., & Kiledjian, M. (2019). Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Nature chemical biology, 15, 575-582. PubMed
• Vajtay, T. J., Bandi, A., Upadhyay, A., Swerdel, M. R., Hart, R. P., Lee, C. R., & Margolis, D. J. (2019). Optogenetic and transcriptomic interrogation of enhanced muscle function in the paralyzed mouse whisker pad. Journal of neurophysiology 121(4):1491-1500. PubMed
• Fantuzzo, J. A., Hart, R. P., Zahn, J. D., & Pang, Z. P. (2019). Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics. Developmental dynamics : an official publication of the American Association of Anatomists, 248, 65-77. PubMed
• Chow, H.-M., A. Cheng, X. Song, M.R. Swerdel, R.P. Hart, K.Herrup (2018) ATM is activated by ATP depletion and modulates mitochondrial function through NRF1. bioRxiv 414490; doi: https://doi.org/10.1101/414490
• Zucco, A. J., Pozzo, V. D., Afinogenova, A., Hart, R. P., Devinsky, O., & D’Arcangelo, G. (2018). Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation. Molecular and cellular neurosciences, 92, 149-163. PubMed
• Tiethof, A. K., Richardson, J. R., & Hart, R. P. (2018). Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells. Toxics, 6. PubMed
• Fantuzzo, J.A., R. P. Hart, J. D. Zahn & Z. P. Pang (2018) Compartmentalized devices as tools for investigation of human brain network dynamics.  Developmental Dynamics. https://doi.org/10.1002/dvdy.24665 PubMed
• McGowan, H., Mirabella, V. R., Hamod, A., Karakhanyan, A., Mlynaryk, N., Moore, J. C., Tischfield, J. A., Hart, R. P., & Pang, Z. P. (2018). hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons. Frontiers in synaptic neuroscience, 10, 19. PubMed
• Tiethof, A.K., J.R. Richardson & R.P. Hart (2018) Knockdown of butyrylcholinesterase but not inhibition by chlorpyrifos alters early differentiation mechanisms in human neural stem cells. bioRxiv https://doi.org/10.1101/354308
• Prytkova, I., Goate, A., Hart, R. P., & Slesinger, P. A. (2018). Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? Alcoholism, clinical and experimental research. PubMed
• Li, W., Huang, Y., Sargsyan, D., Khor, T. O., Guo, Y., Shu, L., Yang, A. Y., Zhang, C., Paredes-Gonzalez, X., Verzi, M., Hart, R. P., & Kong, A. N. (2018). Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq. Cell & bioscience, 8, 3. PubMed
• Halikere, A., D. Popova, A. Hamod, M.R. Swerdel, J.C. Moore, J.A. Tischfield, R.P. Hart & Z.P. Pang (2018) Addiction associated N40D mu-opioid receptor variant modulates synaptic functions in human neurons.  bioRxiv https://doi.org/10.1101/328898
• Eid, A., Bihaqi, S. W., Hemme, C., Gaspar, J. M., Hart, R. P., & Zawia, N. H. (2018). Histone acetylation maps in aged mice developmentally exposed to lead: epigenetic drift and Alzheimer-related genes. Epigenomics, 10, 573-583. PubMed
• Guo, Y., Wu, R., Gaspar, J. M., Sargsyan, D., Su, Z. Y., Zhang, C., Gao, L., Cheng, D., Li, W., Wang, C., Yin, R., Fang, M., Verzi, M. P., Hart, R. P., & Kong, A. N. (2018). DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice. Carcinogenesis, 39, 669-680. PubMed
• Chen, J., Chen, Y., Vail, G., Chow, H., Zhang, Y., Louie, L., Li, J., Hart, R. P., Plummer, M. R., & Herrup, K. (2017). Erratum to: The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. Molecular neurodegeneration, 12, 4. PubMed
• Guo, Y., Su, Z. Y., Zhang, C., Gaspar, J. M., Wang, R., Hart, R. P., Verzi, M. P., & Kong, A. N. (2017). Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq. Biochemical pharmacology, 135, 22-34. PubMed
• Fantuzzo, J. A., Mirabella, V. R., Hamod, A. H., Hart, R. P., Zahn, J. D., & Pang, Z. P. (2017). Intellicount: High-Throughput Quantification of Fluorescent Synaptic Protein Puncta by Machine Learning. eNeuro, 4. PubMed
• Gaspar, J. M., & Hart, R. P. (2017). DMRfinder: efficiently identifying differentially methylated regions from MethylC-seq data. BMC bioinformatics, 18, 528. PubMed
• Fantuzzo, J. A., De Filippis, L., McGowan, H., Yang, N., Ng, Y. H., Halikere, A., Liu, J. J., Hart, R. P., Wernig, M., Zahn, J. D., & Pang, Z. P. (2017). μNeurocircuitry: Establishing in vitro models of neurocircuits with human neurons. Technology, 5, 87-97. PubMed
• Li, Y., Hao, H., Swerdel, M. R., Cho, H. Y., Lee, K. B., Hart, R. P., Lyu, Y. L., & Cai, L. (2017). Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network. Journal of neuroscience research. PubMed
• Jiao, X., Doamekpor, S. K., Bird, J. G., Nickels, B. E., Tong, L., Hart, R. P., & Kiledjian, M. (2017). 5′ End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Cell, 168, 1015-1027.e10. PubMed
• Guo, Y., Su, Z. Y., Zhang, C., Gaspar, J. M., Wang, R., Hart, R. P., Verzi, M. P., & Kong, A. T. (2017). Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: transcriptomic analysis using RNA-seq. Biochemical pharmacology, 135: 22-34. PubMed
• Oni, E.N., A. Halikere, G. Li, A. J. Toro-Ramos, M. R. Swerdel, J. L. Verpeut, J. C. Moore, N. T. Bello, L. J. Bierut, A. Goate, J. A. Tischfield, Z. P. Pang & R. P. Hart (2016) Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele. Scientific Reports 6: 34341  PubMed
• Oni, E.N. and R.P. Hart (2016) Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse. Current Pharmacology Reports, 2, 203.
• Chen, J., Chen, Y., Vail, G., Chow, H., Zhang, Y., Louie, L., Li, J., Hart, R. P., Plummer, M. R., & Herrup, K. (2016). The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. Molecular neurodegeneration, 11, 60. PubMed
• Hart, R. P., & Goff, L. A. (2016). Long Noncoding RNAs: Central to Nervous System Development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. PubMed
• Popovitchenko, T., Thompson, K., Viljetic, B., Jiao, X., Kontonyiannis, D.L., Kiledjian, M., Hart, R.P., Rasin, M.R. (2016) The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex. Scientific Reports, doi: 10.1038/srep28998 PubMed
• De Filippis, L., Halikere, A., McGowan, H., Moore, J. C., Tischfield, J. A., Hart, R. P., & Pang, Z. P. (2016). Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Molecular brain, 9, 51. PubMed
• Carlson, A. L., Bennett, N. K., Francis, N. L., Halikere, A., Clarke, S., Moore, J. C., Hart, R. P., Paradiso, K., Wernig, M., Kohn, J., Pang, Z. P., & Moghe, P. V. (2016). Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds. Nature communications, 7, 10862. PubMed
• Grudzien-Nogalska, E., Jiao, X., Song, M. G., Hart, R. P., & Kiledjian, M. (2016). Nudt3 is an mRNA decapping enzyme that modulates cell migration. RNA (New York, N.Y.), 22, 773-81. PubMed
• Lin, L., Swerdel, M. R., Lazaropoulos, M. P., Hoffman, G. S., Toro-Ramos, A. J., Wright, J., Lederman, H., Chen, J., Moore, J. C., & Hart, R. P. (2015). Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line. Stem cell reports, 5, 1097-108. PubMed
• Jiang, D., Zhang, Y., Hart, R. P., Chen, J., Herrup, K., & Li, J. (2015). Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain : a journal of neurology. PubMed
• Kraushar, M. L., Viljetic, B., Wijeratne, H. R., Thompson, K., Jiao, X., Pike, J. W., Medvedeva, V., Groszer, M., Kiledjian, M., Hart, R. P., & Rasin, M. R. (2015). Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35, 10911-26. PubMed
• Guo, Y., Lee, J. H., Shu, L., Huang, Y., Li, W., Zhang, C., Yang, A. Y., Boyanapalli, S. S., Perekatt, A., Hart, R. P., Verzi, M., & Kong, A. N. (2015). Association of aberrant DNA methylation in Apc(min/+) mice with the epithelial-mesenchymal transition and Wnt/ß-catenin pathways: genome-wide analysis using MeDIP-seq. Cell & bioscience, 5, 24. PubMed
• Carmel, J. B., Young, W., & Hart, R. P. (2015). Flipping the transcriptional switch from myelin inhibition to axon growth in the CNS. Frontiers in molecular neuroscience, 8, 34. PubMed
• Siddiq, M. M., Hannila, S. S., Carmel, J. B., Bryson, J. B., Hou, J., Nikulina, E., Willis, M. R., Mellado, W., Richman, E. L., Hilaire, M., Hart, R. P., & Filbin, M. T. (2015). Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. The Journal of biological chemistry, 290, 16343-56. PubMed
• Xie, P., Moore, C. R., Swerdel, M. R., & Hart, R. P. (2014). Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice. Genomics data, 2, 386-388. PubMed
• Davila, J. L., Goff, L. A., Ricupero, C. L., Camarillo, C., Oni, E. N., Swerdel, M. R., Toro-Ramos, A. J., Li, J., & Hart, R. P. (2014). A positive feedback mechanism that regulates expression of miR-9 during neurogenesis. PloS one, 9, e94348. PubMed
• Yang, A. Y., Lee, J. H., Shu, L., Zhang, C., Su, Z. Y., Lu, Y., Huang, M. T., Ramirez, C., Pung, D., Huang, Y., Verzi, M., Hart, R. P., & Kong, A. N. (2014). Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models. Life sciences, 113, 45-54. PubMed
• Edwards, S., Baron, J., Moore, C. R., Liu, Y., Perlman, D. H., Hart, R. P., & Xie, P. (2014). Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. Journal of hematology & oncology, 7, 56.
• Kraushar, M. L., Thompson, K., Wijeratne, H. R., Viljetic, B., Sakers, K., Marson, J. W., Kontoyiannis, D. L., Buyske, S., Hart, R. P., & Rasin, M. R. (2014). Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. Proceedings of the National Academy of Sciences of the United States of America, 111, E3815-24. PubMed
• Ricupero, C. L., Swerdel, M. R., & Hart, R. P. (2013). Epigenome analysis of pluripotent stem cells. Methods in molecular biology (Clifton, N.J.), 997, 203-16. PubMed
• Li, J., Hart, R. P., Mallimo, E. M., Swerdel, M. R., Kusnecov, A. W., & Herrup, K. (2013). EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nature neuroscience, 16, 1745-53. PubMed
• Sauvageau, M., Goff, L. A., Lodato, S., Bonev, B., Groff, A. F., Gerhardinger, C., Sanchez-Gomez, D. B., Hacisuleyman, E., Li, E., Spence, M., Liapis, S. C., Mallard, W., Morse, M., Swerdel, M. R., D’Ecclessis, M. F., Moore, J. C., Lai, V., Gong, G., Yancopoulos, G. D., Frendewey, D., Kellis, M., Hart, R. P., Valenzuela, D. M., Arlotta, P., & Rinn, J. L. (2013). Multiple knockout mouse models reveal lincRNAs are required for life and brain development. eLife, 2, e01749. PubMed
• DeBoer, E. M., Kraushar, M. L., Hart, R. P., & Rasin, M. R. (2013). Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons. Neuroscience, 248, 499-528. PubMed
• Hannila, S. S., Siddiq, M. M., Carmel, J. B., Hou, J., Chaudhry, N., Bradley, P. M., Hilaire, M., Richman, E. L., Hart, R. P., & Filbin, M. T. (2013). Secretory Leukocyte Protease Inhibitor Reverses Inhibition by CNS Myelin, Promotes Regeneration in the Optic Nerve, and Suppresses Expression of the Transforming Growth Factor-ß Signaling Protein Smad2. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 5138-51. PubMed
• Komlos, D., Mann, K. D., Zhuo, Y., Ricupero, C. L., Hart, R. P., Liu, A. Y., & Firestein, B. L. (2013). Glutamate dehydrogenase 1 and SIRT4 regulate glial development. Glia, 61, 394-408. PubMed
• Mahishi, L. H., Hart, R. P., Lynch, D. R., & Ratan, R. R. (2012). miR-886-3p levels are elevated in Friedreich ataxia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32, 9369-73.
• Pichardo-Casas, I., Goff, L. A., Swerdel, M. R., Athie, A., Davila, J., Ramos-Brossier, M., Lapid-Volosin, M., Friedman, W. J., Hart, R. P., & Vaca, L. (2012). Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation. Brain research, 1436, 20-33.
• Li, H., Hader, A. T., Han, Y. R., Wong, J. A., Babiarz, J., Ricupero, C. L., Godfrey, S. B., Corradi, J. P., Fennell, M., Hart, R. P., Plummer, M. R., & Grumet, M. (2012). Isolation of a novel rat neural progenitor clone that expresses Dlx family transcription factors and gives rise to functional GABAergic neurons in culture. Developmental neurobiology, 72, 805-20. PubMed
• Li, J., Chen, J., Ricupero, C. L., Hart, R. P., Schwartz, M. S., Kusnecov, A., & Herrup, K. (2012). Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nature medicine, 18, 783-90. PubMed
• Ma, L., Yu, Y. M., Guo, Y., Hart, R. P., & Schachner, M. (2012). Cysteine- and glycine-rich protein 1a is involved in spinal cord regeneration in adult zebrafish. The European journal of neuroscience, 35, 353-65. PubMed
• Camarillo, C., Swerdel, M., & Hart, R. P. (2011). Comparison of microarray and quantitative real-time PCR methods for measuring MicroRNA levels in MSC cultures. Methods in molecular biology (Clifton, N.J.), 698, 419-29. PubMed
• Yu, Y. M., Gibbs, K. M., Davila, J., Campbell, N., Sung, S., Todorova, T. I., Otsuka, S., Sabaawy, H. E., Hart, R. P., & Schachner, M. (2011). MicroRNA miR-133b is essential for functional recovery after spinal cord injury in adult zebrafish. The European journal of neuroscience, 33, 1587-97. PubMed
• Guo, Y., Ma, L., Cristofanilli, M., Hart, R. P., Hao, A., & Schachner, M. (2011). Transcription factor Sox11b is involved in spinal cord regeneration in adult zebrafish. Neuroscience, 172, 329-41. PubMed
• Moore, J. C., Atze, K., Yeung, P. L., Toro-Ramos, A. J., Camarillo, C., Thompson, K., Ricupero, C. L., Brenneman, M. A., Cohen, R. I., & Hart, R. P. (2010). Efficient, high-throughput transfection of human embryonic stem cells. Stem cell research & therapy, 1, 23. PubMed
• Lakshmipathy, U., Davila, J., & Hart, R. P. (2010). miRNA in pluripotent stem cells. Regenerative medicine, 5, 545-55. PubMed
• Bail, S., Swerdel, M., Liu, H., Jiao, X., Goff, L. A., Hart, R. P., & Kiledjian, M. (2010). Differential regulation of microRNA stability. RNA (New York, N.Y.), 16, 1032-9. PubMed
• Moore, J. C., Sadowy, S., Alikani, M., Toro-Ramos, A. J., Swerdel, M. R., Hart, R. P., & Cohen, R. I. (2010). A high-resolution molecular-based panel of assays for identification and characterization of human embryonic stem cell lines. Stem cell research, 4, 92-106. PubMed
• Goff, L. A., Davila, J., Swerdel, M. R., Moore, J. C., Cohen, R. I., Wu, H., Sun, Y. E., & Hart, R. P. (2009). Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. PloS one, 4, e7192. PubMed
• Chang, Y. W., Goff, L. A., Li, H., Kane-Goldsmith, N., Tzatzalos, E., Hart, R. P., Young, W., & Grumet, M. (2009). Rapid induction of genes associated with tissue protection and neural development in contused adult spinal cord after radial glial cell transplantation. Journal of neurotrauma, 26, 979-93. PubMed
• Li, H., Han, Y. R., Bi, C., Davila, J., Goff, L. A., Thompson, K., Swerdel, M., Camarillo, C., Ricupero, C. L., Hart, R. P., Plummer, M. R., & Grumet, M. (2008). Functional differentiation of a clone resembling embryonic cortical interneuron progenitors. Developmental neurobiology, 68, 1549-64. PubMed
• Goff, L. A., Boucher, S., Ricupero, C. L., Fenstermacher, S., Swerdel, M., Chase, L. G., Adams, C. C., Chesnut, J., Lakshmipathy, U., & Hart, R. P. (2008). Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. Experimental hematology, 36, 1354-1369. PubMed
• Li, H., Chang, Y. W., Mohan, K., Su, H. W., Ricupero, C. L., Baridi, A., Hart, R. P., & Grumet, M. (2008). Activated Notch1 maintains the phenotype of radial glial cells and promotes their adhesion to laminin by upregulating nidogen. Glia, 56, 646-58. PubMed
• Goff, L. A., Davila, J., Jörnsten, R., Keles, S., & Hart, R. P. (2007). Bioinformatic analysis of neural stem cell differentiation. Journal of biomolecular techniques : JBT, 18, 205-12. PubMed
• Porter, J. F., Sharma, S., Wilson, D. L., Kappil, M. A., Hart, R. P., & Denhardt, D. T. (2005). Tissue inhibitor of metalloproteinases-1 stimulates gene expression in MDA-MB-435 human breast cancer cells by means of its ability to inhibit metalloproteinases. Breast cancer research and treatment, 94, 185-93. PubMed
• Goff, L. A., Yang, M., Bowers, J., Getts, R. C., Padgett, R. W., & Hart, R. P. (2005). Rational probe optimization and enhanced detection strategy for microRNAs using microarrays. RNA biology, 2, 93-100. PubMed
• Jones, T. B., Hart, R. P., & Popovich, P. G. (2005). Molecular control of physiological and pathological T-cell recruitment after mouse spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25, 6576-83.
• Goff, L. A., Bowers, J., Schwalm, J., Howerton, K., Getts, R. C., & Hart, R. P. (2004). Evaluation of sense-strand mRNA amplification by comparative quantitative PCR. BMC genomics, 5, 76. PubMed
• Hu, R., Hebbar, V., Kim, B. R., Chen, C., Winnik, B., Buckley, B., Soteropoulos, P., Tolias, P., Hart, R. P., & Kong, A. N. (2004). In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. The Journal of pharmacology and experimental therapeutics, 310, 263-71. PubMed
• Pan, J. Z., Jörnsten, R., & Hart, R. P. (2004). Screening anti-inflammatory compounds in injured spinal cord with microarrays: a comparison of bioinformatics analysis approaches. Physiological genomics, 17, 201-14. PubMed
• Weeks, J., & Hart, R. P. (2004). SCI-Base: an open-source spinal cord injury animal experimentation database. Lab animal, 33, 35-41. PubMed
• Carmel, J. B., Kakinohana, O., Mestril, R., Young, W., Marsala, M., & Hart, R. P. (2004). Mediators of ischemic preconditioning identified by microarray analysis of rat spinal cord. Experimental neurology, 185, 81-96. PubMed
• Li, H., Berlin, Y., Hart, R. P., & Grumet, M. (2003). Microtubules are critical for radial glial morphology: possible regulation by MAPs and MARKs. Glia, 44, 37-46. PubMed
• Pan, J. Z., Ni, L., Sodhi, A., Aguanno, A., Young, W., & Hart, R. P. (2002). Cytokine activity contributes to induction of inflammatory cytokine mRNAs in spinal cord following contusion. Journal of neuroscience research, 68, 315-22. PubMed
• Nesic, O., Svrakic, N. M., Xu, G. Y., McAdoo, D., Westlund, K. N., Hulsebosch, C. E., Ye, Z., Galante, A., Soteropoulos, P., Tolias, P., Young, W., Hart, R. P., & Perez-Polo, J. R. (2002). DNA microarray analysis of the contused spinal cord: effect of NMDA receptor inhibition. Journal of neuroscience research, 68, 406-23.
• Jones, T. B., Basso, D. M., Sodhi, A., Pan, J. Z., Hart, R. P., MacCallum, R. C., Lee, S., Whitacre, C. C., & Popovich, P. G. (2002). Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22, 2690-700. PubMed
• Carmel, J. B., Galante, A., Soteropoulos, P., Tolias, P., Recce, M., Young, W., & Hart, R. P. (2001). Gene expression profiling of acute spinal cord injury reveals spreading inflammatory signals and neuron loss. Physiological genomics, 7, 201-13. PubMed
• Kim, W. K., Kan, Y., Ganea, D., Hart, R. P., Gozes, I., & Jonakait, G. M. (2000). Vasoactive intestinal peptide and pituitary adenylyl cyclase-activating polypeptide inhibit tumor necrosis factor-alpha production in injured spinal cord and in activated microglia via a cAMP-dependent pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20, 3622-30. PubMed
• Bai, Y., & Hart, R. P. (1998). Cultured sympathetic neurons express functional interleukin-1 receptors. Journal of neuroimmunology, 91, 43-54. PubMed
• Carlson, C. D., Bai, Y., Ding, M., Jonakait, G. M., & Hart, R. P. (1996). Interleukin-1 involvement in the induction of leukemia inhibitory factor mRNA expression following axotomy of sympathetic ganglia. Journal of neuroimmunology, 70, 181-90. PubMed
• Carlson, C. D., Bai, Y., Jonakait, G. M., & Hart, R. P. (1996). Interleukin-1 beta increases leukemia inhibitory factor mRNA levels through transient stimulation of transcription rate. Glia, 18, 141-51. PubMed
• Carlson, C. D., & Hart, R. P. (1996). Activation of acidic sphingomyelinase and protein kinase C zeta is required for IL-1 induction of LIF mRNA in a Schwann cell line. Glia, 18, 49-58. PubMed
• McCormack, R. J., Hart, R. P., & Ganea, D. (1996). Expression of NK-1 receptor mRNA in murine T lymphocytes. Neuroimmunomodulation, 3, 35-46. PubMed
• Ding, M., Hart, R. P., & Jonakait, G. M. (1995). Tumor necrosis factor-alpha induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor. Journal of neurobiology, 28, 445-54. PubMed
• Kuchinke, W., Hart, R. P., & Jonakait, G. M. (1995). Identification of mRNAs regulated by interferon-gamma in cultured rat astrocytes by PCR differential display. Neuroimmunomodulation, 2, 347-55. PubMed
• Liu, C., Bai, Y., Ganea, D., & Hart, R. P. (1995). Species-specific activity of rat recombinant interleukin-1 beta. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 15, 985-92. PubMed
• Jonakait, G. M., & Hart, R. P. (1995). Immune cytokine regulation of sympathetic ganglion response to injury. Neuroimmunomodulation, 2, 236-40. PubMed
• Ding, M., Hart, R. P., Shadiack, A. M., & Jonakait, G. M. (1994). The interleukin-1-induced increase of substance P in sympathetic ganglia is not mediated by ciliary neurotrophic factor. Journal of neuroscience research, 38, 640-7. PubMed
• Harrell, R. A., & Hart, R. P. (1994). Rapid preparation of Thermus flavus DNA polymerase. PCR methods and applications, 3, 372-5. PubMed
• Jonakait, G. M., Wei, R., Sheng, Z. L., Hart, R. P., & Ni, L. (1994). Interferon-gamma promotes cholinergic differentiation of embryonic septal nuclei and adjacent basal forebrain. Neuron, 12, 1149-59. PubMed
• Shadiack, A. M., Carlson, C. D., Ding, M., Hart, R. P., & Jonakait, G. M. (1994). Lipopolysaccharide induces substance P in sympathetic ganglia via ganglionic interleukin-1 production. Journal of neuroimmunology, 49, 51-8. PubMed
• Factor, E. M., Hart, R. P., & Jonakait, G. M. (1993). Neurochemical development of the raphe after continuous prenatal cocaine exposure. Brain research bulletin, 31, 49-56. PubMed
• Shadiack, A. M., Hart, R. P., Carlson, C. D., & Jonakait, G. M. (1993). Interleukin-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitory factor (LIF). The Journal of neuroscience : the official journal of the Society for Neuroscience, 13, 2601-9. PubMed
• Hart, R. P., Liu, C., Shadiack, A. M., McCormack, R. J., & Jonakait, G. M. (1993). An mRNA homologous to interleukin-1 receptor type I is expressed in cultured rat sympathetic ganglia. Journal of neuroimmunology, 44, 49-56. PubMed
• Riley, L. A., Jonakait, G. M., & Hart, R. P. (1993). Serotonin modulates the levels of mRNAS coding for thyrotropin-releasing hormone and preprotachykinin by different mechanisms in medullary raphe neurons. Brain research. Molecular brain research, 17, 251-7. PubMed
• Jonakait, G. M., Ni, L., Walker, P. D., & Hart, R. P. (1991). Development of substance P (SP)-containing cells in the central nervous system: consequences of neurotransmitter co-localization. Progress in neurobiology, 36, 1-21. PubMed
• Walker, P. D., Ni, L., Riley, L. A., Jonakait, G. M., & Hart, R. P. (1991). Serotonin innervation affects SP biosynthesis in rat neostriatum. Annals of the New York Academy of Sciences, 632, 485-7. PubMed
• Riley, L. A., Walker, P. D., Hart, R. P., & Jonakait, G. M. (1991). Alterations of preprotachykinin (PPT) mRNA in medullary raphe occur following manipulation of serotonin. Annals of the New York Academy of Sciences, 632, 455-6. PubMed
• Walker, P. D., Green, T. L., Jonakait, G. M., & Hart, R. P. (1991). A comparison of substance P peptide and preprotachykinin mRNA levels during development of rat medullary raphe and neostriatum. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 9, 47-55. PubMed
• Jonakait, G. M., Schotland, S., & Hart, R. P. (1991). Effects of lymphokines on substance P in injured ganglia of the peripheral nervous system. Annals of the New York Academy of Sciences, 632, 19-30. PubMed
• Walker, P. D., Riley, L. A., Hart, R. P., & Jonakait, G. M. (1991). Serotonin regulation of neostriatal tachykinins following neonatal 6-hydroxydopamine lesions. Brain research, 557, 31-6. PubMed
• Hart, R. P., Shadiack, A. M., & Jonakait, G. M. (1991). Substance P gene expression is regulated by interleukin-1 in cultured sympathetic ganglia. Journal of neuroscience research, 29, 282-91. PubMed
• Riley, L. A., Hart, R. P., & Jonakait, G. M. (1991). Both zimelidine and clorgyline decrease preprotachykinin mRNA in adult medullary raphe nuclei. Molecular and cellular neurosciences, 2, 139-44. PubMed
• Walker, P. D., Riley, L. A., Hart, R. P., & Jonakait, G. M. (1991). Serotonin regulation of tachykinin biosynthesis in the rat neostriatum. Brain research, 546, 33-9. PubMed
• Hart, R. P., Yang, R., Riley, L. A., & Green, T. L. (1991). Post-transcriptional control of tryptophan hydroxylase gene expression in rat brain stem and pineal gland. Molecular and cellular neurosciences, 2, 71-7. PubMed
• Jonakait, G. M., Schotland, S., & Hart, R. P. (1990). Interleukin-1 specifically increases substance P in injured sympathetic ganglia. Annals of the New York Academy of Sciences, 594, 222-30. PubMed
• Walker, P. D., Schotland, S., Hart, R. P., & Jonakait, G. M. (1990). Tryptophan hydroxylase inhibition increases preprotachykinin mRNA in developing and adult medullary raphe nuclei. Brain research. Molecular brain research, 8, 113-9. PubMed
• Green, T. L., & Hart, R. P. (1988). Mutations in poly(A) site downstream elements affect in vitro cleavage activity. Molecular and cellular biology, 8, 1839-41. PubMed
• McDevitt, M. A., Hart, R. P., Wong, W. W., & Nevins, J. R. (1986). Sequences capable of restoring poly(A) site function define two distinct downstream elements. The EMBO journal, 5, 2907-13.
• Hart, R. P., McDevitt, M. A., & Nevins, J. R. (1985). Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences. Cell, 43, 677-83.
• Hart, R. P., McDevitt, M. A., Ali, H., & Nevins, J. R. (1985). Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sites. Molecular and cellular biology, 5, 2975-83.
• Imperiale, M. J., Hart, R. P., & Nevins, J. R. (1985). An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription. Proceedings of the National Academy of Sciences of the United States of America, 82, 381-5.
• Hart, R. P., & Folk, W. R. (1982). Structure and organization of a mammalian 5 S gene cluster. The Journal of biological chemistry, 257, 11706-11.
• Triezenberg, S. J., Rushford, C., Hart, R. P., Berkner, K. L., & Folk, W. R. (1982). Structure of the Syrian hamster ribosomal DNA repeat and identification of homologous and nonhomologous regions shared by human and hamster ribosomal DNAs. The Journal of biological chemistry, 257, 7826-33.